Interleukin-12: A master regulator

Interleukin-12: A master regulator

Early resistance to pathogens requires a swift response from NK cells. In 1989, Giorgio Trinchieri identified an NK growth factor and activator, later called interleukin-12 (IL-12). This discovery helped reveal the regulatory link between innate and adaptive immunity.

What is a Master Regulator?

Copyright: © 2013 Chan SSK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The term “master regulator” or “master regulatory gene” was first coined by Susumu Ohno over 30 years ago for a “gene that occ...

mTOR: The Master Regulator

Themammalian targetof rapamycin (mTOR)kinase integratescues fromnutrientsandgrowth factors, acting as a nexus point for cellular signals to control growth,metabolism, and longevity. Deregulation ofeitherofmTOR’s twocomplexes,mTORC1ormTORC2, leads todiseasesofmetabolism, including cancer and diabetes. In this issue’s Select, insights into the extent of mTOR’s oncogenic capabilities come to light...

A K-12 Master Plan

A Master Regulator of the Pancreatic Program

Over the last decade, it has been discovered that the transcription factor Sox9 plays several critical roles in governing the development of the embryonic pancreas and the homeostasis of the mature organ. While analysis of pancreata from patients affected by the Sox9 haploinsufficiency syndrome campomelic dysplasia initially alluded to a functional role of Sox9 in pancreatic morphogenesis, tran...